Anthony Hopkins, Jodie Foster, Julianne Moore
Manhunter actually corresponds to the book featuring the Red Dragon.
This is one of the most interesting mind-thrillers I have ever enjoyed. The books, links below, are also recommended for those whose imaginations can create a richer tapestry than any DVD might offer.
The new DVD, Hannibal Rising, is also superb and credible and I review it separately. Here is the link to the book and the DVD.
Anthony Hopkins is the gold standard, but I must give full credit to the actors in Manhunter and Hannibal Rising, they are superb. While I missed Jody Foster, whose Silence of the Lambs performance was extraordinary, Julianne Moore is amazing, and fully her equal.
This set, both books and DVDs, is for the intellectual connosieur.